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Recruiting Trials

Recruiting Trials

Cardiology

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Cardiology

Stenosis

DynamX Bioadaptor

Age ≥ 20
Myocardial ischemia
Be able to undergo PTCA, stenting and CABG

By Specialist Referral
Trial for eligible patients at Middlemore Hospital.

Coronary artery stenosis

DESyne BDS

Age ≥ 18
Be able to undergo percutaneous intervention and CABG.

By Specialist Referral
Trial for eligible patients at Middlemore Hospital.

Acute Coronary Syndrome

AEGIS-II (CSL112_3001)

Type 1 Myocardial infarction
Have at least two coronary artery territories of disease > 50%
Be on treatment for Diabetes

By Specialist Referral
Trial for eligible patients currently an inpatient at Middlemore Hospital.

Gastroenterology / Hepatology

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Gastroenterology / Hepatology

Non-alcoholic Steatohepatitis

MK-3655-001-00 (NASH)

Male or postmenopausal female, aged 18-80 years old, diagnosed Nonalcoholic Steatohepatitis, no other chronic liver disease

See if you qualify

Ulcerative colitis

AVOGADRO-UC (Ulcerative colitis)

Age less than 65 years, have diagnosed ulcerative colitis and experiencing increase in daily stool frequency and/or rectal bleeding, no allergy to antibiotic vancomycin, willing to undergo two colonoscopy procedures as part of the study (3 months apart)

See if you qualify

Chronic Hepatitis B

VIR (VIR-2218)

Aged 18 to 65
Chronic Hepatitis B infection
On stable NUC treatment (e.g Entecavir orTenofovir)

See if you qualify

Haematology

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Haematology

Multiple Myeloma

BGB-11417-105

Age ≥ 18
Diagnosed with Relapsed or Refractory Multiple Myeloma
No long-term use of Prednisone

By Specialist Referral
Ask your Haematologist if this is right for you.

Multiple Myeloma

FRAIL-M

Age ≥ 18
Newly diagnosed multiple myeloma
Ineligible for autologous stem cell transplant
No prior treatment for multiple myeloma except localised radiotherapy or a short course of steroids

By Specialist Referral
Ask your Haematologist if this is right for you.

Myelodysplastic Syndrome (MDS)

KER050 (Anemia in MDS)

Age ≥ 18
Diagnosed with Myelodysplastic Syndrome (MDS)
Anemia

See if you qualify

Multiple Myeloma

DREAMM8

Age ≥ 18
Diagnosed with Relapsed or Refractory Multiple Myeloma.

By Specialist Referral
Ask your Haematologist if this is right for you.

Infectious Diseases

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Infectious Diseases

Viral Respiratory Disease

SHIVERS

Viral respiratory disease
Acute presentation to Middlemore Emergency Department or Intensive care unit

By Specialist Referral
Trial for eligible patients with acute presentation at Middlemore Hospital.

Staphylococcus aureus infection

SNAP

Staphylococcus aureus bloodstream infection
Admitted to hospital

By Specialist Referral
Trial for eligible patients at Middlemore Hospital.

Respiratory Syncytial Virus

RSV study

Healthy woman aged between 18 and 49 years of age
Pregnant with no known increased risk for complications
Singleton pregnancy

See if you qualify

Staphylococcus aureus infection

S. aureus Vaccine

Are 18-64 years of age.
Have a current/recent skin infection.
No ongoing illness or history of serious chronic/progressive disease.

See if you qualify

COVID-19 Infection

ASCOT

Age ≥ 18 years
Admitted to an acute-care hospital
Confirmed SARS-CoV-2 by nucleic acid testing in the 14 days prior to randomisation

By Specialist Referral
Trial for eligible patients at Middlemore Hospital.

Oncology

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Oncology

Colorectal Adenoma

The OSCAR Trial

Advanced colorectal adenoma at first colonoscopy in the National Bowel Screening Programme
No residual colorectal adenomas
Next colonoscopy planned within 5 years

By Specialist Referral
Trial for eligible patients at Middlemore Hospital.

Paediatrics

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Paediatrics

Acute Lower Respiratory Infection (ALRI)

PETAL

Indigenous (Australian Aboriginal and/or Torres Strait Islander; or New Zealander Maori and/or Pacific Islander)
Hospitalised with an ALRI (bronchiolitis or pneumonia)
Required oxygen or respiratory support at any point of illness (including transfer and in the community) OR fluid support (NG or IV) OR recurrent admission within 3 months
Aged ≥ 3 months

By Specialist Referral
Trial for eligible patients at Kidz First, Middlemore Hospital.

Plastics and Burns

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Plastics and Burns

Wound healing

NPWT

Age ≥ 18
Be undergoing a surgical procedure resulting in a closed approximately linear incision

By Specialist Referral
Trial for eligible patients at Middlemore Hospital.

Renal

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Renal

End Stage Kidney Disease (ESKD)

Phosphate Trial

Age ≥45 years, or Age ≥18 years with diabetes.
ESKD treated with haemodialysis, or peritoneal dialysis, for at
least 3 months.
Prescribed at least one phosphate-lowering medication at any
dose.

By Specialist Referral
Trial for eligible patients at Middlemore Hospital.

IgA Nephropathy

The Align Study

Age ≥ 18
Diagnosed with IgA Nephropathy
On a stable dose of an ACE inhibitor or ARB / unable to tolerate this therapy.

See if you qualify

Respiratory

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Respiratory

Severe Asthma

Choosebetweenamab

Aged >12 years
Diagnosed and confirmed with asthma
Have had asthma for at least 1 year
Evidence of past or current atopy
Total serum human IgE ≥ 30 IU/ml
Eosinophil count ≥ 300 cells microliter in last 12 months or ≥150 cells per microlitre while on oral corticosteroids in the last 12 months

By Specialist Referral
Trial for eligible patients at Middlemore Hospital.

Bronchiectasis

ASPEN

Aged 18-85, diagnosed non-cystic fibrosis bronchiectasis, two or more exacerbations in the past 12 months.

See if you qualify

Chronic obstructive pulmonary disease

PACE

Aged between 40 and 85 years
Diagnosed with COPD
A history of cardiovascular disease, including heart failure, ischaemic heart disease, tachyarrhythmias, and hypertension

See if you qualify

Bronchiectasis

Resveratrol

Age ≥ 18
Confirmed diagnosis of bronchiectasis within 5 years
Pulmonary exacerbation requiring antibiotics in the past 12 months

See if you qualify

Rheumatology

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Rheumatology

Polymyalgia Rheumatica

HUBBLE PMR

Aged between 50-80.
Have been diagnosed with Polymyalgia Rheumatica (PMR).
Have experienced improvement in PMR symptoms with Prednisone.

See if you qualify

Giant Cell Arthritis

Select - GCA (M16-852)

Age ≥ 50
Diagnosed Giant Cell Arthritis
Headache, jaw pain, vision loss
Shoulder and/or hip pain

See if you qualify

Spinal Unit

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Spinal Unit

Wound healing

FPH Spinal

Age ≥ 22
Undergoing 1 or 2 level spinal decompression

By Specialist Referral
Trial for eligible patients at Middlemore Hospital.

Spinal cord injury

AFES

Age >18
Acute tetraplegic patients

By Specialist Referral
Trial for eligible patients with acute presentation at Middlemore Hospital.

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About Us

Middlemore Clinical Trials is a fully integrated research unit based at Middlemore Hospital in the heart of South Auckland, New Zealand.

We perform biopharma and medical device clinical trials in partnership with all hospital departments focusing on the diseases and Long term health conditions that affect our diverse community.

Our Contacts

Phone: +64 9 270 9758
Email: info@mmclintrials.nz